HSP90 Inhibitors: Current Development and Potential in Cancer Therapy

ISSN: 2212-3970 (Online)
ISSN: 1574-8928 (Print)

Volume 10, 3 Issues, 2015

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HSP90 Inhibitors: Current Development and Potential in Cancer Therapy

Author(s): Katerina Sidera and Evangelia Patsavoudi

Affiliation: Dept. of Biochemistry, Hellenic Pasteur Institute, 127, Vas. Sofias Av., 11521 Athens, Greece.


In the last decade, the molecular chaperone HSP90 has emerged as an important target in cancer therapeutics and has subsequently become the focus of several drug discovery and development efforts. The first-in-class HSP90 inhibitor 17-AAG entered into Phase I clinical trial in 1999. Today 13 HSP90 inhibitors representing multiple drug classes, with different modes of action, are undergoing clinical evaluation. The present review will highlight the involvement of HSP90 in regulating and maintaining the transformed phenotype, provide an overview on current HSP90 inhibitors and further update on the most relevant patents which have recently appeared in the literature.

Keywords: Cancer therapeutics, cell surface, chaperoning, drug discovery, HSP90, signal transduction.

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Article Details

Volume: 9
Issue Number: 1
First Page: 1
Last Page: 20
Page Count: 20
DOI: 10.2174/15748928113089990031

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