New Improved Drug Delivery Technologies for Pentacyclic Triterpenes: A Review

ISSN: 1875-5305 (Online)
ISSN: 0929-8665 (Print)


Volume 21, 12 Issues, 2014


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Protein & Peptide Letters

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University of Florida
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New Improved Drug Delivery Technologies for Pentacyclic Triterpenes: A Review

Author(s): Codruta Soica, Cristina Trandafirescu, Corina Danciu, Danina Muntean, Cristina Dehelean and Georgeta Simu

Affiliation: Faculty of Pharmacy, University of Medicine and Pharmacy ,Victor Babes”Timisoara.

Abstract

Phytochemicals are becoming more and more interesting in the field of therapeutic research, mainly in the treatment of chronic illnesses, due to the fact that many synthetic drugs cause important side effects that impact on pa- tient’s life quality. Pentacyclic triterpenes are a class of compounds with several therapeutic effects and increasing impor- tance in cancer therapy; however, a major disadvantage is their low water solubility and bioavailability which leads to rather poor therapeutic results in vivo.Technological attempts to improve the pharmacokinetic profile of the main repre- sentatives of this class include the use of cyclodextrins, micro- and nanoemulsions, liposomes, polymeric nanoparticles, and nanocapsules. This paper is aimed to briefly summarize the most significant achievements in this field.

Keywords: Bioavailability, cyclodextrin, liposome, nanoparticle, solubility, triterpenes.

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Article Details

Volume: 21
Issue Number: 11
First Page: 1137
Last Page: 1145
Page Count: 9
DOI: 10.2174/0929866521666140807115109
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