New Improved Drug Delivery Technologies for Pentacyclic Triterpenes: A Review
Protein & Peptide Letters,
Codruta Soica, Cristina Trandafirescu, Corina Danciu, Danina Muntean, Cristina Dehelean and Georgeta SimuAffiliation:
Faculty of Pharmacy, University of Medicine and Pharmacy ,Victor Babes”Timisoara.
AbstractPhytochemicals are becoming more and more interesting in the field of therapeutic research, mainly in the treatment of chronic illnesses, due to the fact that many synthetic drugs cause important side effects that impact on pa- tient’s life quality. Pentacyclic triterpenes are a class of compounds with several therapeutic effects and increasing impor- tance in cancer therapy; however, a major disadvantage is their low water solubility and bioavailability which leads to rather poor therapeutic results in vivo.Technological attempts to improve the pharmacokinetic profile of the main repre- sentatives of this class include the use of cyclodextrins, micro- and nanoemulsions, liposomes, polymeric nanoparticles, and nanocapsules. This paper is aimed to briefly summarize the most significant achievements in this field.
Bioavailability, cyclodextrin, liposome, nanoparticle, solubility, triterpenes.
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