Recent Advances in Protein and Peptide Drug Delivery: A Special Emphasis on Polymeric Nanoparticles

ISSN: 1875-5305 (Online)
ISSN: 0929-8665 (Print)


Volume 21, 12 Issues, 2014


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Protein & Peptide Letters

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Prof. Ben M. Dunn
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University of Florida
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Recent Advances in Protein and Peptide Drug Delivery: A Special Emphasis on Polymeric Nanoparticles

Author(s): ASHABEN PATEL, MITESH PATEL, XIAOYAN YANG and ASHIM K. MITRA

Affiliation: University of Missouri Curators Professor of Pharmacy Chairman, Pharmaceutical Sciences Vice-Provost for Interdisciplinary Research University of Missouri - Kansas City School of Pharmacy, 2464 Charlotte Street, Kansas City, MO 64108, USA

Abstract

Proteins and peptides are widely indicated in many disease states. Parenteral route is a most commonly employed method of administration for therapeutic proteins and peptides. However, requirement of frequent injections due to short in vivo half-life results in poor patience compliance. Non-invasive routes such as nasal, pulmonary, transdermal and oral offer several advantages over parenteral administration. Intrinsic physicochemical properties and low permeability across biological membrane limit protein delivery via non-invasive routes. One of the strategies to improve protein and peptide absorption is by delivering through nanostructured delivery carriers. Among nanocarriers, polymeric nanoparticles (NPs) have demonstrated significant advantages over other delivery systems. This article summarizes the application of polymeric NPs for protein and peptide drug delivery following oral, nasal, pulmonary, parenteral, transdermal, and ocular administrations


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Article Details

Volume: 21
First Page: 1
Page Count: 1
DOI: 10.2174/0929866521666140807114240
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