Solid Lipid Nanoparticles Loaded with Fluorescent-labelled Cyclosporine A: Anti-Inflammatory Activity In Vitro

ISSN: 1875-5305 (Online)
ISSN: 0929-8665 (Print)


Volume 21, 12 Issues, 2014


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Protein & Peptide Letters

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University of Florida
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Solid Lipid Nanoparticles Loaded with Fluorescent-labelled Cyclosporine A: Anti-Inflammatory Activity In Vitro

Author(s): Marina Gallarate, Loredana Serpe, Federica Foglietta, Gian Paolo Zara, Susanna Giordano, Elena Peira, Daniela Chirio and Luigi Battaglia

Affiliation: Universita degli Studi di Torino, Dipartimento di Scienza e Tecnologia del Farmaco, Via Pietro Giuria 9, Torino, Italy.

Abstract

FMOC-isocyclosporine A, a fluorescent labeled cyclosporine A, was encapsulated in solid lipid nanoparticles (SLN) prepared by the coacervation technique, and its anti-inflammatory activity was evaluated. The anti-inflammatory activity of the fluorescent labelled molecule, measured as inhibition of TNF-α secretion, is similar to the native one. SLN were compared to commercial formulations, through measurement of cytokine release and drug uptake in rat peripheral blood mononuclear cells. Drug-loaded SLN inhibit TNF-α secretion in a lower extent than commercial formulations, probably due to a lower uptake by the cells, but the increase of IL-10 secretion caused by the lipid matrix itself makes this formulation interesting for its anti-inflammatory activity.

Keywords: Coacervation, cyclosporine A, cytokines, FMOC, inflammation, solid lipid nanoparticles.

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Article Details

Volume: 21
Issue Number: 11
First Page: 1157
Last Page: 1162
Page Count: 6
DOI: 10.2174/0929866521666140806164410
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