Solid Lipid Nanoparticles: An Innovative Nano-Vehicles for Drug Delivery
Hema Chaudhary, Samita, Nitika Puri and Vikash KumarAffiliation:
PDM College of Pharmacy, Bahadurgarh, Haryana, India.
AbstractNanotechnology is an emergent field with numerous applications in drug delivery, clinical medicine, nutriceuticals as well as in other fields also. In this techno, Solid lipid nanoparticles (SLN) is a part which consist solid colloidal particles ranging in size from 1 to 1000 nm and act as “magic bullet” when coupled with ligands/targeting ligands. SLN consisting of a solid-lipid promising advance delivery of lipophilic drugs and also used as an alternate for conventional carriers such as micro-emulsions, liposomes and nanoparticles based on natural/synthetic polymers. They are formulated from synthetic/natural lipids and optimize the drug delivery to provide a protection to sensitive drugs and obtain better/improve bioavailability with less toxicity (as compared to polymeric NPs) due to its biodegradable/bioacceptable nature. Moreover, Surface Modified SLNs is a new promising approach for protein loading and antigen delivery system.
Nanotechnology, solid lipid nanoparticles (SLN), drug delivery, toxicity.
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