Design, Synthesis, and Antitumor Activity of Novel Acylate of 6-OH at 1- O-acetylbritannilactone

ISSN: 1875-6638 (Online)
ISSN: 1573-4064 (Print)


Volume 11, 8 Issues, 2015


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Medicinal Chemistry

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Design, Synthesis, and Antitumor Activity of Novel Acylate of 6-OH at 1- O-acetylbritannilactone



Medicinal Chemistry, 11(2): 200-205.

Author(s): Shouxin Liu, Jun Feng, He Liu, Junzhang Li and Xia Tian.

Affiliation: State Key Laboratory Breeding Base, Hebei Laboratory of Molecular Chemistry for Drug, College of Chemical and Pharmaceutical Engineering, Hebei University of Science & Technology, Shijiazhuang 050018, P.R. China.

Abstract

N-(α-Alkyloxime-3-phenylpropionyl) proline was designed and synthesized as an acylating agent to modify the 6-OH of 1-O-acetylbritannilactone. Eight intermediates and eight target compounds were obtained. The structures of sixteen novel compounds were characterized by 1HNMR, IR and HRMS. The activities against HL-60 and Bel-7402 cell lines were tested, the IC50 values of compound IVg were 2.7 μM and 4.3 μM, respectively.




Keywords:

Acylation compound, antitumor, britannilactone, synthesis.



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Article Details

Volume: 11
Issue Number: 2
First Page: 200
Last Page: 205
Page Count: 6
DOI: 10.2174/1573406410666140815123216
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