Design, Synthesis, and Antitumor Activity of Novel Acylate of 6-OH at 1-O-Acetylbritannilactone

ISSN: 1875-6638 (Online)
ISSN: 1573-4064 (Print)


Volume 10, 8 Issues, 2014


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Medicinal Chemistry

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Editor-in-Chief:
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Kings College
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Design, Synthesis, and Antitumor Activity of Novel Acylate of 6-OH at 1-O-Acetylbritannilactone

Author(s): Shouxin Liu, Jun Feng, He Liu, Junzhang Li and Xia Tian

Affiliation: State Key Laboratory Breeding Base, Hebei Laboratory of Molecular Chemistry for Drug, College of Chemical and Pharmaceutical Engineering, Hebei University of Science & Technology, Shijiazhuang 050018, P. R. China

Abstract

N-(α-Alkyloxime-3-phenylpropionyl) proline was designed and synthesized as an acylating agent to modify the 6-OH of 1-O-acetylbritannilactone. Eight intermediates and eight target compounds were obtained. The structures of sixteen novel compounds were characterized by 1HNMR, IR and HRMS. The activities against HL-60 and Bel-7402 cell lines were tested, the IC50 values of compound IVg were 2.7 µM and 4.3 µM, respectively


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Article Details

Volume: 10
First Page: 1
Page Count: 1
DOI: 10.2174/1573406410666140815123216
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