Green Synthesis and Antioxidant Activity of Novel γ-Cyano-α- hydroxyphosphonate Derivatives

ISSN: 1875-6638 (Online)
ISSN: 1573-4064 (Print)


Volume 11, 8 Issues, 2015


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Medicinal Chemistry

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Green Synthesis and Antioxidant Activity of Novel γ-Cyano-α- hydroxyphosphonate Derivatives

Author(s): Iyadh Aouani, Karima Lahbib and Soufiane Touil

Affiliation: Laboratory of Heteroatom Organic Chemistry, Department of Chemistry, Faculty of Sciences of Bizerta, University of Carthage, 7021-Jarzouna, Tunisia.

Abstract

Herein we report an efficient, simple and green synthesis of novel types of α-hydroxyphosphonates bearing a nitrile group, from the reaction of γ-ketonitriles with dialkyl phosphites in the presence of magnesium oxide as solid support, under solvent-free conditions. All the title compounds were screened for their antioxidant activity by 1,1-diphenyl-2- picrylhydrazyl (DPPH), hydroxyl radical, reducing power and ferrous ion chelating (FIC) methods and they showed significant antioxidant activity.




Keywords: α-Hydroxyphosphonates, γ-cyano-α-hydroxyphosphonates, γ-ketonitriles, green synthesis, antioxidant activity.

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Article Details

Volume: 11
Issue Number: 2
First Page: 206
Last Page: 213
Page Count: 8
DOI: 10.2174/1573406410666140706154046
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