Functionalization of Tetracycline and Evaluation of its Antibacterial Activity Including Against Resistant Bacteria

ISSN: 1875-6638 (Online)
ISSN: 1573-4064 (Print)


Volume 10, 8 Issues, 2014


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Medicinal Chemistry

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Kings College
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Functionalization of Tetracycline and Evaluation of its Antibacterial Activity Including Against Resistant Bacteria

Author(s): Priyanka Dogra and Ghanshyam S. Chauhan

Affiliation: Department of Chemistry, Himachal Pradesh University, Summer Hill, Shimla-171 005 India

Abstract

Ever growing resistance by the pathogenic bacteria against the prevalent antibiotics has forced the researchers to look for new methods and techniques to design effective antimicrobial agents. In the present study a new tetracycline-based antimicrobial polymer (AMP) was synthesized via acryloylation method using lipase-catalyzed esterification of tetracycline with methacrylic acid (MAAc). The aforesaid polymer was transformed into nanoparticles by an emulsion method. These polymers were characterized by various techniques, i.e., FTIR, NMR, XRD, SEM, and EDAX. The antibacterial activity of the AMPs was studied against two bacteria P. aeruginosa [resistant (-)] and S. aureus [susceptible (+)]. The synthesized AMP was observed to be more potent and efficient antimicrobial agent than the precursor tetracycline


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Article Details

Volume: 10
First Page: 1
Last Page: 1
Page Count: 1
DOI: 10.2174/1573406410666140507094435
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