Inflammation Fueling Atrial Fibrillation Substrate: Seeking Ways to “Cool” the Heart

ISSN: 1875-6638 (Online)
ISSN: 1573-4064 (Print)


Volume 10, 8 Issues, 2014


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Medicinal Chemistry

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Editor-in-Chief:
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Kings College
University of Cambridge
Cambridge
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Inflammation Fueling Atrial Fibrillation Substrate: Seeking Ways to “Cool” the Heart

Author(s): Georgios Giannopoulos, Michael W Cleman and Spyridon Deftereos

Affiliation: Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, USA

Abstract

Atrial fibrillation (AF) is the most common chronic arrhythmia and a source of significant morbidity and mortality. Previous studies have identified numerous risk factors for the development of AF, including hypertension, diabetes mellitus and heart failure, which have known pathophysiologic links with inflammatory processes. The importance of inflammation in inducing and perpetuating AF has been highlighted not only by experimental, epidemiological and cohort observational studies, but also by clinical trials providing evidence that inflammatory pathways are involved in AF pathogenesis. Local and systemic measurements of biomarkers and inflammatory mediators, as well as atrial biopsy studies have also given insight as to the purported relationship between this arrhythmia and inflammation. However, the link between inflammation and AF is still poorly defined and several issues remain unresolved.The present review offers an overview of existing evidence supporting the “inflammatory” hypothesis for AF pathophysiology and potential therapeutic means for counteracting this “foul interplay” between arrhythmia and inflammation

Keywords: Anti-inflammatory, atrial fibrillation, CRP, inflammation, interleukin

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Article Details

Volume: 10
First Page: 1
Last Page: 9
Page Count: 9
DOI: 10.2174/1573406410666140318110100
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