Synthesis of Novel 2-(Methylthio)benzo[g][1,2,4]triazolo[1,5-a]quinazolin- 5-(4H)-one and its Derivatives

ISSN: 1875-6255 (Online)
ISSN: 1570-1786 (Print)


Volume 11, 10 Issues, 2014


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Synthesis of Novel 2-(Methylthio)benzo[g][1,2,4]triazolo[1,5-a]quinazolin- 5-(4H)-one and its Derivatives

Author(s): Rashad A. Al-Salahi, Mohamed S. Marzouk, Hazem A. Ghabbour and Fun H. Kun

Affiliation: Department of Chemistry, King Saud University, P.O. Box 2457, Riyadh 11451, Saudia Arabia and Chemistry of Natural Products Research Group, Center of Excellence for Advanced Sciences, National Research Center, Dokki, 12622, Cairo, Egypt.

Abstract

A novel 2-(methylthio)benzo[g][1,2,4]triazolo[1,5-a]quinazolin-5(4H)-one was synthesized employing dimethyl N-cyanoimidodithiocarbonate and 3-hydrazinyl-2-naphthoic acid as building blocks. Chemical transformation of the inherent lactam group in the target molecule provided access to a variety of heterocylic derivatives. The obtained compounds are characterized and confirmed by NMR, IR, and HREI-MS analyses.




Keywords: 3-hydrazinyl-2-naphthoic acid, cyclocondensation, dimethyl N-cyanoimidodithiocarbonate.

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Article Details

Volume: 11
Issue Number: 10
First Page: 759
Last Page: 767
Page Count: 9
DOI: 10.2174/1570178611666140813205111
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