Ultrasound-promoted One-pot Synthesis of 2-Thioxo-dihydropyrimidine Derivatives Bearing Piperidinylamide Moiety

ISSN: 1875-6255 (Online)
ISSN: 1570-1786 (Print)


Volume 11, 10 Issues, 2014


Download PDF Flyer




Letters in Organic Chemistry

Aims & ScopeAbstracted/Indexed in


Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Miguel Yus
Universidad de Alicante Apdo
Alicante
Spain


View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 0.648
5 - Year: 0.665

Ultrasound-promoted One-pot Synthesis of 2-Thioxo-dihydropyrimidine Derivatives Bearing Piperidinylamide Moiety

Author(s): Bao-Hua Chen, Ji-Tai Li, Rui-Jia Lan and Guo-Feng Chen

Affiliation: College of Chemistry and Environmental Science, Hebei University, Wusi East Road No.180, Baoding 071002, P.R. China.

Abstract

A convenient and efficient one-pot synthesis of 2-thioxo-dihydropyrimidine derivatives bearing piperidinylamide moiety is described. The reactions were carried out in 81-91% yields via the condensation of 1-(piperidin-1- yl)butane-1,3-dione with aromatic aldehyde and thiourea in ethanol catalyzed by p-toluenesulfonic acid at room temperature under ultrasound irradiation. The advantages of this methodology are convenient operation, mild conditions, short reaction times and high yields.




Keywords: Catalysis, condensation, one-pot synthesis, piperidinylamide, 2-thioxo-dihydropyrimidine, ultrasound irradiation.

Purchase Online Rights and Permissions

  
  



Article Details

Volume: 11
Issue Number: 9
First Page: 643
Last Page: 650
Page Count: 8
DOI: 10.2174/1570178611666140707183047
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science