Facile Synthesis of Novel N<sup>4</sup>-Substituted 2-(Trifluoromethyl)-tetrahydrobenzothieno[ 2,3-d]pyrimidine Derivatives

ISSN: 1875-6255 (Online)
ISSN: 1570-1786 (Print)

Volume 13, 10 Issues, 2016

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Letters in Organic Chemistry

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Miguel Yus
Universidad de Alicante Apdo

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Facile Synthesis of Novel N4-Substituted 2-(Trifluoromethyl)-tetrahydrobenzothieno[ 2,3-d]pyrimidine Derivatives

Letters in Organic Chemistry, 11(9): 700-705.

Author(s): Fasong Wang, Hui Gao, Ping Yang, Yan Wang and Xinjian Song.

Affiliation: Key Laboratory of Biologic Resources Protection and Utilization of Hubei Province, Hubei Minzu University, Xueyuan Road, Enshi, Hubei 445000, P.R. China.


A series of novel N4-substituted 2-(trifluoromethyl)-tetrahydrobenzothieno[2,3-d]pyrimidine derivatives were synthesized by a facile three-step procedure that presented such advantages as easily accessible starting materials, mild reaction conditions, simple protocol and good overall yields. The structures of the title compounds were confirmed by IR, 1H NMR, 13C NMR, EI-MS, elemental analysis, and single-crystal X-ray diffraction.


Facile synthesis, crystal structure, Gewald reaction, thieno[2, 3-d]pyrimidines, fluorinated compounds.

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Article Details

Volume: 11
Issue Number: 9
First Page: 700
Last Page: 705
Page Count: 6
DOI: 10.2174/1570178611666140609225422

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