A Rapid Click Chemistry Using Beta-Cyclodextrin Immobilized on Glass Micro-Particles

ISSN: 1875-6255 (Online)
ISSN: 1570-1786 (Print)

Volume 14, 10 Issues, 2017

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Letters in Organic Chemistry

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Miguel Yus
Universidad de Alicante Apdo

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A Rapid Click Chemistry Using Beta-Cyclodextrin Immobilized on Glass Micro-Particles

Letters in Organic Chemistry, 10(4): 269-276.

Author(s): Muhammad Nazir Tahir, Riaz-ul Qamar, Petra Mischnick, Jaebum Kim and Seunho Jung.

Affiliation: Department of Bioscience and Biotechnology, Konkuk University, Seoul 143-701, Republic of Korea.


The surface of glass micro-particle (GMP) was functionalized with β-cyclodextrin (→ GMP-β-CD) and was characterized by X-ray photoelectron spectroscopy (XPS). GMP-β-CD was used as a phase transfer catalyst for click reactions of aromatic azides with terminal acetylenes. For click reaction of benzyl azide and phenyl acetylene, reaction time was decreased from 5.8 h to 10 min when 0.8g GMP-β-CD /mmol of benzyl azide was added. The modified surface of GMP-β-CD showed no change or degradation after repeated use as confirmed from XPS analysis after 10 cycles.


β-Cyclodextrin, click chemistry, glass micro-particles, phase transfer catalyst, surface functionalization.

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Article Details

Volume: 10
Issue Number: 4
First Page: 269
Last Page: 276
Page Count: 8
DOI: 10.2174/1570178611310040008
Price: $58

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