Pd/C-catalyzed Synthesis of (E)-2-arylmethylideneindolin-3-ols Under Ultrasound: Their Initial Evaluation as Potential Anti-proliferative Agents
Letters in Drug Design & Discovery,
Ponugubati Radhakrishna Murthi, Namburi Suresh, Chekuri Sharmila Rani, Mandava Venkata Basaveswara Rao and Manojit PalAffiliation:
Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Hyderabad-500 046, India.
Abstract(E)-2-Arylmethylideneindolin-3-ol derivatives have been explored as new and potential anti-proliferative agents. Synthesis of these compounds was carried out by using a Pd/C-catalyzed alternative and one-pot method involving C-C coupling of 1-(2-(p-tosylamino)phenyl)prop-2-yn-1-ol with a range of iodoarenes followed by intramolecular hydroamination in the same pot. The reaction proceeded faster when performed under ultrasound irradiation. All these compounds showed selective growth inhibition of MDA-MB 231 cancer cells.
Cancer, coupling, hydroamination, indolin-3-ol, Pd/C.
Purchase Online Order Reprints Order Eprints Rights and Permissions