Pd/C-catalyzed Synthesis of (E)-2-arylmethylideneindolin-3-ols Under Ultrasound: Their Initial Evaluation as Potential Anti-proliferative Agents

ISSN: 1875-628X (Online)
ISSN: 1570-1808 (Print)


Volume 11, 10 Issues, 2014


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Pd/C-catalyzed Synthesis of (E)-2-arylmethylideneindolin-3-ols Under Ultrasound: Their Initial Evaluation as Potential Anti-proliferative Agents

Author(s): Ponugubati Radhakrishna Murthi, Namburi Suresh, Chekuri Sharmila Rani, Mandava Venkata Basaveswara Rao and Manojit Pal

Affiliation: Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Hyderabad-500 046, India.

Abstract

(E)-2-Arylmethylideneindolin-3-ol derivatives have been explored as new and potential anti-proliferative agents. Synthesis of these compounds was carried out by using a Pd/C-catalyzed alternative and one-pot method involving C-C coupling of 1-(2-(p-tosylamino)phenyl)prop-2-yn-1-ol with a range of iodoarenes followed by intramolecular hydroamination in the same pot. The reaction proceeded faster when performed under ultrasound irradiation. All these compounds showed selective growth inhibition of MDA-MB 231 cancer cells.




Keywords: Cancer, coupling, hydroamination, indolin-3-ol, Pd/C.

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Article Details

Volume: 12
Issue Number: 2
First Page: 109
Last Page: 116
Page Count: 8
DOI: 10.2174/1570180811666140819224103
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