ISSN: 1875-628X (Online)
ISSN: 1570-1808 (Print)
Volume 12, 10 Issues, 2015
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Design, Synthesis and Biological Evaluation of Benzimidazole-pyridine- Piperidine Hybrids as a New Class of Potent Antimicrobial Agents
Letters in Drug Design & Discovery, 12
): 38-45.Author(s): Kothapally. Beulah
, Akula Ravi Kumara
, Boddupally Peda Venkat Lingaiah
, Pamulaparthy Shanthan Rao
, Banda Narsaiah
, Aaramadaka Sunil Kumar Reddy
and Upadhyayula Surya Narayana Murty
Fluoroorganic Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad- 500007, India.
AbstractA series of novel benzimidazole-pyridine-piperidine hybrids was synthesized in good yields and characterized by spectral and elemental analyses. The compounds 4a-h and 5a-c were evaluated for their in vitro antibacterial activity against gram-positive organisms viz., Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermidis, gramnegative organisms viz., Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia and also against fungal strains like Candida albicans, Saccharomyces cervisiae of yeasts, Aspergillus flavus, Aspergillus niger according to the CLSI Standard Protocol. Compound 5a showed promising activity against all tested organism excluding Bacillus subtilis when compared to standard drugs.
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