Synthesis and Evaluation of Bis-pyrazolineDerivatives as Potential Antimicrobial Agents

ISSN: 1875-628X (Online)
ISSN: 1570-1808 (Print)

Volume 11, 10 Issues, 2014

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Letters in Drug Design & Discovery

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Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge

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Synthesis and Evaluation of Bis-pyrazolineDerivatives as Potential Antimicrobial Agents

Author(s): Mehlika Dilek Altıntop, Usama Abu Mohsen, Hulya Karaca, Zerrin Cantürk and Ahmet Ozdemir

Affiliation: Anadolu University Faculty of Pharmacy Department of Pharmaceutical Chemistry 26470 Eskişehir Turkey.


In the present study, 5,5ꞌ-(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-(4-arylthiazol-2-yl)] derivatives (3a-h) were obtainedvia the reaction of 5,5ꞌ-(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide] (2) with phenacyl bromides. The synthesized compounds were investigated for their antimicrobial activity against various bacteria and Candida species.Among these derivatives,5,5ꞌ-(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-(4-(4-chlorophenyl)thiazol-2-yl)](3b) and 5,5ꞌ-(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-(4-(4-methoxyphenyl)thiazol-2-yl)](3d)showed notable antimicrobial activity.

Keywords: Antimicrobial activity, Pyrazole, Thiazole

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Article Details

Volume: 11
First Page: 1
Last Page: 5
Page Count: 5
DOI: 10.2174/1570180811666140717185937

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