Synthesis and Evaluation of Bis-pyrazoline Derivatives as Potential Antimicrobial Agents
Letters in Drug Design & Discovery,
Mehlika Dilek Altıntop, Usama Abu Mohsen, Hulya Karaca, Zerrin Canturk and Ahmet OzdemirAffiliation:
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eski sehir 26470, Turkey.
AbstractIn the present study, 5,5 '-(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-(4-arylthiazol-2-yl)] derivatives (3a-h) were obtained via the reaction of 5,5' -(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1- carbothioamide] (2) with phenacyl bromides. The synthesized compounds were investigated for their antimicrobial activity against various bacteria and Candida species. Among these derivatives, 5,5' -(1,4-phenylene)bis[3-(2-thienyl)-4,5- dihydro-1H-pyrazole-1-(4-(4-chlorophenyl)thiazol-2-yl)] (3b) and 5,5' -(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1Hpyrazole- 1-(4-(4-methoxyphenyl)thiazol-2-yl)] (3d) showed notable antimicrobial activity.
Antimicrobial activity, pyrazole, thiazole.
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