Synthesis and Bioactivity of Novel Carvacrol and Thymol Derivatives Containing 5-Phenyl-2-furan
Zining Cui, Xinghai Li and Yoshihiro NishidaAffiliation:
Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Department of Plant Pathology, College of Natural Resource and Environment, South China Agricultural University, Guangzhou 510642, China.
AbstractA series of novel carvacrol and thymol derivatives containing 5-phenyl-2-furan were synthesized. The antitumor tests showed that the title compounds exhibited promising activity against Bel-7402 and KB. The fungicidal tests showed that most of the title compounds had a considerable effect on the selected fungi. Generally the bioactivity of the carvacrol and its derivatives were better than that of the thymol and its derivatives. The substituted groups on the orthoand para- positions gave better activity than that of ones on the meta-position.
Synthesis, 5-Phenyl-2-furan, Carvacrol and thymol derivatives, Antitumor activity, Antifungal activity.
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