A Potential Anticancer Agent 1,2-di(quinazolin-4-yl)diselane

ISSN: 1875-628X (Online)
ISSN: 1570-1808 (Print)


Volume 14, 12 Issues, 2017


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Letters in Drug Design & Discovery

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A Potential Anticancer Agent 1,2-di(quinazolin-4-yl)diselane



Letters in Drug Design & Discovery, 11(6): 731-735.

Author(s): Yinjiu Huang, Gang Liu, Xiaomei Hu, Hao Liu, Jianguo Hu, Zhenzhong Feng, Bi Tang, Jun Qian, Qiyi Wang and Xuehui Long.

Affiliation: School of Chemistry and Materials Science, Ludong University, Yantai 264025, PR China.

Abstract

The development of antitumor drugs with novel effects is urgent for cancer patients. In our recent anticancer drug discovery study, 1,2-di(quinazolin-4-yl)diselane (LG003) was synthesized and showed considerable antitumor effects on six tested cancer cell lines in vitro. Morphological observation and Lactate Dehydrogenase release assay revealed that LG003 exerted such effect in A549 cells through antiproliferation, apoptosis or other pathway rather than cytotoxicity which suggests that compound LG003 is a potential antitumor agent.




Keywords:

1, 2-di(quinazolin-4-yl)diselane, Anticancer activity, Cytotoxicity, A549, Anticancer agent, Breast cancer.



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Article Details

Volume: 11
Issue Number: 6
First Page: 731
Last Page: 735
Page Count: 5
DOI: 10.2174/1570180811666140214204858
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