The Role of NO-cGMP Signaling Pathway in Pancreatic Beta-cell Function

ISSN: 1875-5844 (Online)
ISSN: 1871-5222 (Print)


Volume 14, 3 Issues, 2014


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Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Immunology, Endocrine and Metabolic Agents

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Editor-in-Chief:
Ryuichi Morishita
Department of Clinical Gene Therapy
School of Medicine
Osaka University
2-2 Yamada-oka, Suita 565-0871
Japan


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The Role of NO-cGMP Signaling Pathway in Pancreatic Beta-cell Function

Author(s): Maria-Luisa Lazo-de-la-Vega-Monroy and Alonso Vilches-Flores

Affiliation: Departamento de Ciencias Medicas, División de Ciencias de la Salud, Universidad de Guanajuato Campus Leon. 20 de Enero No. 929 Col. Obregon, 37320 León, Guanajuato, Mexico.

Abstract

Insulin-secretion in pancreatic beta-cells is modulated by several second messengers and complex signaling pathways. Nitric oxide has been usually associated with beta-cell apoptosis, as part of the physiopathology of Type-2 diabetes. However there is increasing evidence that NO/cGMP signaling pathway is also involved in the secretory function through the activation of some target proteins such as the modulation of glucokinase activity, ionic channels, protein kinases, phosphodiesterases; and gene expression through the activation of transcription factors. These observations could be useful to establish new therapeutic strategies to maintain beta-cell optimal response before the development of islet dysfunction that leads to diabetes.

Keywords: Ca2+ channels, cGMP, insulin secretion, insulin transcription, Nitric oxide, pancreatic beta-cell, PKG, soluble Guanylate Cyclase.

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Article Details

Volume: 14
Issue Number: 1
First Page: 8
Last Page: 14
Page Count: 7
DOI: 10.2174/1871522214666140116213815
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