The Role of No-Cgmp Signaling Pathway in Pancreatic Beta-Cell Function
Maria-Luisa Lazo-de-la-Vega-Monroy and Alonso Vilches-FloresAffiliation:
Departamento de Ciencias Médicas, División de Ciencias de la Salud, Universidad de Guanajuato Campus León., 20 de Enero No. 929 Col. Obregón, 37320 León, Guanajuato, México.
AbstractInsulin-secretion in pancreatic beta-cells is modulated by several second messengers and complex signaling pathways. Nitric oxide has been usually associated with beta-cell apoptosis as part of the physiopathology of Type-2 diabetes, however there are increasing evidences that NO/cGMP signaling pathway is also involved in the secretory function through the activation of some target proteins, like modulation of glucokinase activity, ionic channels, protein kinases, phosphodiesterases, and gene expression through the activation of transcription factors. These observations could be useful to establish new therapeutic strategies to maintain beta-cell optimal response before the development of islet dysfunction that leads to diabetes.
Nitric oxide, pancreatic beta-cell, cGMP, soluble Guanylate Cyclase, PKG, insulin secretion, insulin transcription, Ca2+ channels
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