An Angiotensin Converting Enzyme Inhibitor Suppresses Contrast Media Induced Renal Dysfunction in a Murine Model of Subtotal Nephrectomy

ISSN: 1875-5844 (Online)
ISSN: 1871-5222 (Print)


Volume 14, 3 Issues, 2014


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Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Immunology, Endocrine and Metabolic Agents

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Editor-in-Chief:
Ryuichi Morishita
Department of Clinical Gene Therapy
School of Medicine
Osaka University
2-2 Yamada-oka, Suita 565-0871
Japan


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An Angiotensin Converting Enzyme Inhibitor Suppresses Contrast Media Induced Renal Dysfunction in a Murine Model of Subtotal Nephrectomy

Author(s): Masahito Ogawa, Jun-ichi Suzuki and Mitsuaki Isobe

Affiliation: Department of Advanced Clinical Science and Therapeutics, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.

Abstract

Backgrounds: Contrast media (CM)-induced nephropathy (CIN) affects morbidity and mortality in humans. Although CIN is mediated by several factors including the renin-angiotensin system (RAS), little is known about the pathophysiology. To clarify the mechanism, we developed a novel murine CIN model.

Methods: We made 5/6 subtotal nephrectomy (NTX) and administered CM (iopamidol) intravenously into the mice 4 weeks after NTX. Mice received an angiotensin converting enzyme inhibitor (ACEI, n=6), an angiotensin II receptor blocker (ARB, n=4), or ACEI plus a bradykinin B2 receptor antagonist (Hoe-140, n=5) daily.

Results: Serum creatinine levels were significantly elevated in the NTX group compared to the non-NTX group on day 28. A day after CM injection, creatinine levels were additionally elevated in the non-treated group. While ACEI treatment significantly suppressed the creatinine levels, ARB treatment did not decrease the levels. Hoe-140 negated ACEI’s ability to suppress renal dysfunction.

Conclusion: ACEI treatment may be useful for the prevention of CM-induced nephropathy.


Keywords: Angiotensin converting enzyme, bradykinin, contrast media, murine model, renal dysfunction, renin angiotensin system.

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Article Details

Volume: 13
Issue Number: 3
First Page: 176
Last Page: 184
Page Count: 9
DOI: 10.2174/18715222113139990010
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