ACE and ACE2 in Inflammation: A Tale of Two Enzymes

ISSN: 2212-4055 (Online)
ISSN: 1871-5281 (Print)


Volume 13, 6 Issues, 2014


Download PDF Flyer




Inflammation & Allergy - Drug Targets

Formerly: 'Current Drug Targets - Inflammation & Allergy

Aims & ScopeAbstracted/Indexed in


Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Kurt S Zaenker
Institute of Immunology and Experimental Oncology
University Witten/Herdecke
Stockumerstraße 10
Witten, 58448
Germany


View Full Editorial Board

Subscribe Purchase Articles Order Reprints


ACE and ACE2 in Inflammation: A Tale of Two Enzymes

Author(s): Ravinder Reddy Gaddam, Stephen Chambers and Madhav Bhatia

Affiliation: Inflammation Research Group, Department of Pathology, University of Otago, Christchurch, 2 Riccarton Avenue, P.O. Box 4345, Christchurch 8140, New Zealand.

Abstract

The renin-angiotensin system (RAS) conceived as a coordinated hormonal cascade plays an important role in controlling multiple functions in many organs and is much more complex than previously thought. The RAS has continued to expand, with the identification of new components, functions and subsystems. Angiotensin-converting enzyme (ACE) and its novel homolog angiotensin converting enzyme 2 (ACE2) are two key enzymes involved in the synthesis of bioactive components of the RAS. The main active peptides of the RAS include angiotensin II (Ang II), Ang III, Ang IV, and angiotensin-(1-7) [Ang-(1-7)] among which Ang II and Ang-(1-7) are much more important in health and disease. The axis formed by ACE2 represents an endogenous counter-regulatory pathway within the RAS, and its actions are opposite to those of the ACE axis. Conventionally the RAS has been considered to be important in the cardiovascular system, metabolism, cell growth and homeostasis. In recent years, a key role of ACE and ACE2 and their peptides has been recognized in the inflammatory process in conditions such as cardiac hypertrophy, pulmonary hypertension, glomerulonephritis, lung injury, sepsis, and acute pancreatitis. Investigations are ongoing to better understand the role of the RAS in inflammation. A comprehensive understanding of the RAS components in inflammation can provide new possibilities for therapeutic approaches against inflammatory diseases.

In this review, we discuss our current understanding of the subject, based on recent findings, on the role of ACE and ACE2 in inflammation.





Keywords: Angiotensin II, angiotensin-(1-7), angiotensin-converting enzyme 2, angiotensin-converting enzyme, AT1 receptor, inflammation, Mas receptors, renin-angiotensin system.

Download Free Rights and Permissions

  
  



Article Details

Volume: 13
Issue Number: 4
First Page: 224
Last Page: 234
Page Count: 11
DOI: 10.2174/1871528113666140713164506
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science