Obesity and Oxidative Stress: Potential Roles of Melatonin as Antioxidant and Metabolic Regulator

ISSN: 2212-3873 (Online)
ISSN: 1871-5303 (Print)


Volume 14, 4 Issues, 2014


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Endocrine, Metabolic & Immune Disorders - Drug Targets

Formerly: Current Drug Targets - Immune, Endocrine & Metabolic Disorders

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Editor-in-Chief:
Emilio Jirillo
Universitá degli Studi di Bari
Dipartimento di Clinica Medica
Immunologia e Malattie Infettive
Sezione di Microbiologia e Immunologia
Piazza Giulio Cesare-Policlinico
Bari
Italy


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Obesity and Oxidative Stress: Potential Roles of Melatonin as Antioxidant and Metabolic Regulator

Author(s): Dominique Bonnefont-Rousselot

Affiliation: Service de Biochimie Métabolique, Groupe hospitalier Pitié-Salpêtrière (Assistance Publique – Hôpitaux de Paris), 47-83 boulevard de l’Hôpital, 75651 Paris Cedex 13, France

Abstract

Obesity is associated with an oxidative stress status, defined as an excessive production of reactive oxygen species (ROS) compared to the level of antioxidants acting in the natural defence systems. Several sources of ROS can be identified in obesity (e.g., mitochondrial respiratory chain, or NADPH oxidase) and could contribute to the pathogenesis of obesity. Indeed, these conditions favour the development of insulin resistance and metabolic syndrome through deregulation of adipokines and pro-inflammatory cytokines, so that it could be of interest to associate antioxidant therapeutic strategies with strategies of weight loss. Among antioxidants, melatonin holds a special place, on the one hand for its antioxidant and anti-inflammatory properties, and on the other hand for its role as a metabolic regulator. As melatonin modulates several processes involved in obesity and its related metabolic alterations, it could have a therapeutic interest in the treatment of obesity

Keywords: Antioxidant, insulin resistance, melatonin, metabolic syndrome, obesity

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Article Details

Volume: 14
First Page: 1
Last Page: 10
Page Count: 10
DOI: 10.2174/1871530314666140604151452
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