Immunological Aspects of Metritis in Dairy Cows: A Review
Endocrine, Metabolic & Immune Disorders - Drug Targets,
Marianna Pantaleo, Annalisa Rizzo, Giovanni D'Onghia, Gianfranco D'Onghia, Maria Roncetti, Mariagrazia Piccinno, Maddalena Mutinati, Michele Roberto Terlizzi and Raffaele Luigi SciorsciAffiliation:
Department of the Emergency and Organ Transplantation (D.E.T.O.) – Section of Veterinary Clinics and Animal Production, University of Bari “Aldo Moro”, Strada prov.le per Casamassima km 3 - 70010, Valenzano (BA), Italy.
AbstractThis paper reviews puerperal metritis in the cow, particularly the complex and multi-factorial pathogenesis characterized by an altered cross-talk among infectious agents, endocrine and immune systems. Uterine infections impair fertility and is one of the main causes of economic losses in dairy production. The early postpartum is a period characterized by an increased exposition to infectious agents and the disruption of the metabolic homeostasis, leading to endocrine and immunologic disorders. Dysregulation of uterine defence mechanisms results in the development of metritis. Because there is a complex interaction between infectious, endocrine and immune factors during metritis, there is need to use safer and cheaper drugs which are able to strengthen the anti-infective actions of the routine therapies.
Dairy cow, immunity, metritis, postpartum, uterine, uterus inflammatory diseases.
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