Amiodarone-Induced SIADH: Two Cases Report

ISSN: 2212-3873 (Online)
ISSN: 1871-5303 (Print)

Volume 16, 4 Issues, 2016

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Endocrine, Metabolic & Immune Disorders - Drug Targets

Formerly: Current Drug Targets - Immune, Endocrine & Metabolic Disorders

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Emilio Jirillo
Universit√° degli Studi di Bari
Dipartimento di Clinica Medica
Immunologia e Malattie Infettive
Sezione di Microbiologia e Immunologia
Piazza Giulio Cesare-Policlinico

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Amiodarone-Induced SIADH: Two Cases Report

Endocrine, Metabolic & Immune Disorders - Drug Targets, 14(2): 123-125.

Author(s): Michele Iovino, Nicola Iovine, Antonio Petrosino, Brunella Licchelli, Vito A. Giagulli, Massimo Iacoviello, Edoardo Guastamacchia and Vincenzo Triggiani.

Affiliation: Endocrinology and Metabolic Diseases, Eboli Hospital, Salerno, Italy.


Amiodarone-induced SIADH is a rare but serious side effect of this drug. We report two cases of mild hyponatremia, observed in the last five years, and discuss the role played by age, sex and dose of amiodarone as well as the influence that this molecule may have on aquaporin-2 water channel expression in the renal collecting ducts.


Amiodarone, aquaporin-2, hyponatremia, hypothyroidism, renal collecting ducts, SIADH.

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Article Details

Volume: 14
Issue Number: 2
First Page: 123
Last Page: 125
Page Count: 3
DOI: 10.2174/1871530314666140407111410

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