Phenotypes and Genotypes of High Density Lipoprotein Cholesterol in Exceptional Longevity

ISSN: 1875-6212 (Online)
ISSN: 1570-1611 (Print)


Volume 12, 6 Issues, 2014


Download PDF Flyer




Current Vascular Pharmacology

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 27th of 65 in Peripheral Vascular Disease
  • 84th of 254 in Pharmacology & Pharmacy

Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Dimitri P. Mikhailidis
Academic Head, Deptartment of Clinical Biochemistry
Royal Free Hospital Campus
University College London Medical School
University College London (UCL)
Pond Street
London, NW3 2QG
UK


View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.908
5 - Year: 2.765

Phenotypes and Genotypes of High Density Lipoprotein Cholesterol in Exceptional Longevity

Author(s): Sofiya Milman, Gil Atzmon, Jill Crandall and Nir Barzilai

Affiliation: Institute for Aging Research, Department of Medicine, Division of Endocrinology, 1300, Morris Park Avenue, Bronx, NY 10461, Belfer Building, Suite 701, Albert Einstein College of Medicine.

Abstract

A change in the lipoprotein profile is a metabolic hallmark of aging and has been the target for modern medical developments. Although pharmaceutical interventions aimed at lipid lowering substantially decrease the risk of cardiovascular disease, they have much less impact on mortality and longevity. Moreover, they have not affected death from other age-related diseases. In this review we focus on high density lipoprotein (HDL) cholesterol, the levels of which are either elevated or do not decrease as would be expected with aging in centenarians, and which are associated with lower prevalence of numerous age-related diseases; thereby, suggesting a potential HDL-mediated mechanism for extended survival. We also provide an update on the progress of identifying longevity-mediating lipid genes, describe approaches to discover longevity genes, and discuss possible limitations. Implicating lipid genes in exceptional longevity may lead to drug therapies that prevent several age-related diseases, with such efforts already on the way.

Keywords: Aging, APOC3, CETP, genetics, HDL, longevity.

Purchase Online Order Reprints Order Eprints Rights and Permissions

  
  



Article Details

Volume: 12
Issue Number: 5
First Page: 690
Last Page: 697
Page Count: 8
DOI: 10.2174/1570161111666131219101551
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science