Enantioselective Synthesis of PPAR (Peroxisome Proliferator-Activated Receptors) Agonists and Antagonists

ISSN: 1873-5294 (Online)
ISSN: 1568-0266 (Print)

Volume 15, 24 Issues, 2015

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Current Topics in Medicinal Chemistry

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Allen B. Reitz
Fox Chase Chemical Diversity Center, Inc.
Doylestown, PA

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Enantioselective Synthesis of PPAR (Peroxisome Proliferator-Activated Receptors) Agonists and Antagonists

Current Topics in Medicinal Chemistry, 14(10): 1283-1293.

Author(s): Pilar Goya, Ruth Perez-Fernandez, Rosario Gonzalez-Muniz and Jose Elguero.

Affiliation: Instituto de Quimica Medica, Juan de la Cierva 3, 28006 Madrid, Spain.


This review deals with stereoselective issues in PPAR ligands some of which are in clinical use for treating certain metabolic disorders. After a short introduction of these nuclear receptor and their agonists, some cases of enantioselective separations are reported. The main part concerns stereoselective synthesis first starting with asymmetric synthesis from chiral precursors followed by what we refer to as “true” enantioselective methods. Some examples are discussed in detail for each particular heading.


PPAR, enantioselective separation, enantioselective synthesis, Evans' chiral auxiliary, asymmetric hydrogenation, chiral HPLC, chiral salts.

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Article Details

Volume: 14
Issue Number: 10
First Page: 1283
Last Page: 1293
Page Count: 11
DOI: 10.2174/1568026614666140423112822

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