Asymmetric 1,3-Dipolar Cycloadditons of Stabilized Azomethine Ylides with Nitroalkenes

ISSN: 1873-5294 (Online)
ISSN: 1568-0266 (Print)


Volume 14, 24 Issues, 2014


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Current Topics in Medicinal Chemistry

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Asymmetric 1,3-Dipolar Cycloadditons of Stabilized Azomethine Ylides with Nitroalkenes

Author(s): Carmen Nejera and Jose M. Sansano

Affiliation: Departamento de Quimica Organica and Instituto de Sintesis Organica (ISO). Universidad de Alicante, E-03080-Alicante, Spain.

Abstract

This review highlights the biological importance of many polysubstituted nitro-prolines and -pyrrolidines. Their preparation using asymmetric 1,3-dipolar cycloadditions of azomethine ylides with nitroalkenes using diastereoselective and enantioselective strategies is described remarking the scope and main features of each one.




Keywords: Antitumoral, asymmetric synthesis, catalysis, cycloaddition, metal, organocatalyst.

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Article Details

Volume: 14
Issue Number: 10
First Page: 1271
Last Page: 1282
Page Count: 12
DOI: 10.2174/1568026614666140423112145
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