Chiral Thiazoline and Thiazole Building Blocks for the Synthesis of Peptide- Derived Natural Products

ISSN: 1873-5294 (Online)
ISSN: 1568-0266 (Print)

Volume 15, 24 Issues, 2015

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Current Topics in Medicinal Chemistry

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Allen B. Reitz
Fox Chase Chemical Diversity Center, Inc.
Doylestown, PA

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Chiral Thiazoline and Thiazole Building Blocks for the Synthesis of Peptide- Derived Natural Products

Current Topics in Medicinal Chemistry, 14(10): 1244-1256.

Author(s): Xavier Just-Baringo, Fernando Albericio and Mercedes Alvarez.

Affiliation: Institute for Research in Biomedicine, Barcelona Science Park-University of Barcelona, Baldiri Reixac 10, 08028 Barcelona, Spain.


Thiazoline and thiazole heterocycles are privileged motifs found in numerous peptide-derived natural products of biological interest. During the last decades, the synthesis of optically pure building blocks has been addressed by numerous groups, which have developed a plethora of strategies to that end. Efficient and reliable methodologies that are compatible with the intricate and capricious architectures of natural products are a must to further develop their science. Structure confirmation, structure-activity relationship studies and industrial production are fields of paramount importance that require these robust methodologies in order to successfully bring natural products into the clinic. Today’s chemist toolbox is assorted with many powerful methods for chiral thiazoline and thiazole synthesis. Ranging from biomimetic approaches to stereoselective alkylations, one is likely to find a suitable method for their needs.


Antibiotics, chiral building blocks, peptides, thiazoles, thiazolines, thiopeptides.

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Article Details

Volume: 14
Issue Number: 10
First Page: 1244
Last Page: 1256
Page Count: 13
DOI: 10.2174/1568026614666140423105730

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