Enantioselective Synthesis in Carbohydrate-Based Drug Discovery: Imino Sugars, Alkaloids and Macrolide Antibiotics
Nuno M. Xavier and Amélia P. RauterAffiliation:
Centro de Quimica e Bioquimica, Faculdade de Ciencias, Universidade de Lisboa, Campo Grande, Edificio C8, 5º Piso, 1749-016 Lisboa, Portugal.
AbstractThis review is dedicated to enantioselective methods for the generation of carbohydrate-based lead compounds for drug research. Selected examples encompassing imino sugars, bicyclic imino sugar-type alkaloids such as castanospermine, swainsonine, or alexine, as well as macrolide glycosides are covered and discussed.
Alkaloids, carbohydrates, enantioselective synthesis, imino sugars, macrolide glycosides.
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