Enantioselective Synthesis in Carbohydrate-Based Drug Discovery: Imino Sugars, Alkaloids and Macrolide Antibiotics

ISSN: 1873-5294 (Online)
ISSN: 1568-0266 (Print)


Volume 14, 24 Issues, 2014


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Current Topics in Medicinal Chemistry

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  • 11th of 58 in Chemistry, Medicinal



Editor-in-Chief:
Allen B. Reitz
Fox Chase Chemical Diversity Center, Inc
Doylestown, PA
USA


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Enantioselective Synthesis in Carbohydrate-Based Drug Discovery: Imino Sugars, Alkaloids and Macrolide Antibiotics

Author(s): Nuno M. Xavier and Amélia P. Rauter

Affiliation: Centro de Quimica e Bioquimica, Faculdade de Ciencias, Universidade de Lisboa, Campo Grande, Edificio C8, 5º Piso, 1749-016 Lisboa, Portugal.

Abstract

This review is dedicated to enantioselective methods for the generation of carbohydrate-based lead compounds for drug research. Selected examples encompassing imino sugars, bicyclic imino sugar-type alkaloids such as castanospermine, swainsonine, or alexine, as well as macrolide glycosides are covered and discussed.




Keywords: Alkaloids, carbohydrates, enantioselective synthesis, imino sugars, macrolide glycosides.

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Article Details

Volume: 14
Issue Number: 10
First Page: 1235
Last Page: 1243
Page Count: 9
DOI: 10.2174/1568026614666140423103848
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