Conformational Preferences of Chiral Acyclic Homooligomeric β<sup>2,2</sup>-Peptides

ISSN: 1873-5294 (Online)
ISSN: 1568-0266 (Print)


Volume 14, 24 Issues, 2014


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Current Topics in Medicinal Chemistry

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Conformational Preferences of Chiral Acyclic Homooligomeric β2,2-Peptides

Author(s): Fernando Rodriguez, Francisco Corzana, Alberto Avenoza, Jesus Hector Busto, Jesus Manuel Peregrina and Maria del Mar Zurbano

Affiliation: Departamento de Quimica, Universidad de La Rioja, Centro de Investigacion en Sintesis Quimica, C/ Madre de Dios, 51. 26006 Logrono (La Rioja). Spain.

Abstract

α-Methylisoserine, a chiral acyclic quaternary β-amino acid, has been used to mimic secondary structures, when it is incorporated in a homogeneous β2,2-dipeptide. In particular, the observed folded conformations in aqueous solution can be regarded as mimics of β-turn.




Keywords: β-Peptides, conformational analysis, molecular dynamics, nuclear magnetic resonance.

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Article Details

Volume: 14
Issue Number: 10
First Page: 1225
Last Page: 1234
Page Count: 10
DOI: 10.2174/1568026614666140423101226
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