Progress in Developing Amphiphilic Cyclodextrin-Based Nanodevices for Drug Delivery

ISSN: 1873-5294 (Online)
ISSN: 1568-0266 (Print)


Volume 14, 24 Issues, 2014


Download PDF Flyer




Current Topics in Medicinal Chemistry

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 11th of 58 in Chemistry, Medicinal



Editor-in-Chief:
Allen B. Reitz
Fox Chase Chemical Diversity Center, Inc
Doylestown, PA
USA


View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 3.453
5 - Year: 3.826

Progress in Developing Amphiphilic Cyclodextrin-Based Nanodevices for Drug Delivery

Author(s): Josias B.G. Yameogo, Annabelle Geze, Luc Choisnard, Jean-Luc Putaux, Rasmane Semde and Denis Wouessidjewe

Affiliation: DPM, UMR CNRS 5063, ICMG FR 2607, Faculty of Pharmacy, University of Grenoble, France.

Abstract

Nowadays, colloidal drug carriers represent an alternative to solve drug bioavailabily problems. During the past two decades, colloidal drug carriers have proved to improve the therapeutic index of drugs and thus increase their efficacy and/or reduce their toxicity. However, the major challenge in the development of these drug carriers remains the search for materials able to self-organize into stable nanoscale systems. In particular, amphiphilic α-, β - and γ -cyclodextrins (CDs), grafted on their secondary or primary side with different aliphatic chains, have been investigated as drug delivery vehicles due to their ability to self-assemble and form various stable colloidal systems such as micellar aggregates, nanoreservoirs or nanoparticles exhibiting a matricial, multilamellar or hexagonal supramolecular organization. These self-assembled CD-based nanodevices show some advantages in terms of stability, good ability to associate lipophilic drugs and good in vivo tolerance. This review focuses on the potential of the structured nanoparticles obtained from nonionic amphiphilic CDs in drug delivery and targeting. We discuss the synthesis and characterization of the building blocks as well as the preparation and characterization of colloidal particles made from these materials. We also considered some pharmaceutical applications and identified opportunities for an optimum use of this CD-based nanotechnology approach in addressing worldwide priority health problems.

Keywords: Amphiphilic cyclodextrins, synthesis, characterization, nanoparticles, drug delivery, bioevaluation.

Purchase Online Order Reprints Order Eprints Rights and Permissions

  
  



Article Details

Volume: 14
Issue Number: 4
First Page: 526
Last Page: 541
Page Count: 16
DOI: 10.2174/1568026613666131219125135
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science