Role of Signaling Pathways in Mesenchymal Stem Cell Differentiation
Birru Bhaskar, Naveen Kumar Mekala, Parcha Sreenivasa Rao and Rama Raju BaadheAffiliation:
Department of Biotechnology National Institute of Technology Warangal, 506004, India.
AbstractMesenchymal Stem Cells (MSCs) are self-renewal and differentiate into organized, functional networks of cells. The research in developing clinical applications for MSCs has increased significantly. MSCs are multi potential in proliferation, and are capable to differentiate into cartilage, bone, neuronal cells and adipocytes, etc. Signaling pathways, transcription factors and growth factors modulate the differentiation of MSCs into different cell lineages. Besides, physical factors may regulate the molecular differentiation of stem cells. The main theme of this paper is to review the signaling pathways related to bone morphogenetic proteins (BMPs), epidermal growth factors (EGF), transforming growth factors (TGF), wingless type MMTV integration site (wnt) proteins, fibroblastic growth factor (FGF), and transcriptional regulating factors significance in the MSCs differentiation.
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