Role of Signaling Pathways in Mesenchymal Stem Cell Differentiation

ISSN: 2212-3946 (Online)
ISSN: 1574-888X (Print)

Volume 9, 6 Issues, 2014

Download PDF Flyer

Current Stem Cell Research & Therapy

Aims & ScopeAbstracted/Indexed in

Submit Abstracts Online Submit Manuscripts Online

Anthony Atala
Wake Forest University School of Medicine,
Medical Center Boulevard
Winston Salem, NC 27157

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.861
5 - Year: 3.00

Role of Signaling Pathways in Mesenchymal Stem Cell Differentiation

Author(s): Birru Bhaskar, Naveen Kumar Mekala, Parcha Sreenivasa Rao and Rama Raju Baadhe

Affiliation: Department of Biotechnology National Institute of Technology Warangal, 506004, India.


Mesenchymal Stem Cells (MSCs) are self-renewal and differentiate into organized, functional networks of cells. The research in developing clinical applications for MSCs has increased significantly. MSCs are multi potential in proliferation, and are capable to differentiate into cartilage, bone, neuronal cells and adipocytes, etc. Signaling pathways, transcription factors and growth factors modulate the differentiation of MSCs into different cell lineages. Besides, physical factors may regulate the molecular differentiation of stem cells. The main theme of this paper is to review the signaling pathways related to bone morphogenetic proteins (BMPs), epidermal growth factors (EGF), transforming growth factors (TGF), wingless type MMTV integration site (wnt) proteins, fibroblastic growth factor (FGF), and transcriptional regulating factors significance in the MSCs differentiation.

Purchase Online Rights and Permissions


Article Details

Volume: 9
First Page: 1
Page Count: 1
DOI: 10.2174/1574888X09666140812112002

Related Journals

Webmaster Contact: Copyright © 2014 Bentham Science