Current Role and Future Perspectives of Radioiodinated MIBG in the Evaluation of Dementia with Lewy Bodies
Giorgio Treglia, Luca Ceriani and Luca GiovanellaAffiliation:
Department of Nuclear Medicine and PET/CT Center, Ente Ospedaliero Cantonale, via Ospedale, 12; zip code: 6500; Bellinzona, Switzerland.
AbstractDementia with Lewy bodies (DLB) is the second most common cause of degenerative dementia after Alzheimer’s disease (AD). To improve the diagnosis of DLB, the latest diagnostic criteria incorporate findings from neuroimaging studies including sympathetic innervation imaging with iodine-123-metaiodobenzylguanidine (MIBG). According to these criteria a decreased MIBG myocardial uptake is an important finding supporting a clinical diagnosis of DLB. In this review the state of art and future perspectives of sympathetic innervation imaging by using MIBG in the diagnosis of DLB are discussed.
Dementia with Lewy bodies, dementia, innervation imaging, metaiodobenzylguanidine, MIBG.
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