Current Approaches for New TB Drugs

ISSN: 1875-6387 (Online)
ISSN: 1573-398X (Print)


Volume 11, 4 Issues, 2015


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Current Respiratory Medicine Reviews

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Editor-in-Chief:
Joseph Varon
The University of Texas Health Science Center
Houston, TX
USA


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Current Approaches for New TB Drugs



Current Respiratory Medicine Reviews, 10(2): 88-96.

Author(s): Shilpika Pandey, Isha Soni, Neha Topno, Arunava Dasgupta and Sidharth Chopra.

Affiliation: Division of Microbiology, CSIR-Central Drug Research Institute, B.S. 10/1, Sector 10, Janakipuram Extension, Sitapur Road, Lucknow - 226031, India.

Abstract

Tuberculosis is essentially a curable disease but inspite of a WHO approved DOTS therapy, it still continues to ravage mankind. This situation is exacerbated by long course of chemotherapy, increasing drug resistance and co-emergence with HIV. The TB drug pipeline remained stagnant for a long time with no new drug approved till FDA approval for Bedaquiline. This situation has now improved with a number of agents in pre-clinical and clinical development against M. tuberculosis. In this review, we are focusing on some of the newer drugs in discovery and preclinical development against M. tuberculosis.




Keywords:

Clinical strains, drugs, MIC, Mycobacterium, pre-clinical development, tuberculosis.



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Article Details

Volume: 10
Issue Number: 2
First Page: 88
Last Page: 96
Page Count: 9
DOI: 10.2174/1573398X10666140813201210
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