Resistin and Oxidative Stress as Markers of Atherosclerosis in Obstructive Sleep Apnea

ISSN: 1875-6387 (Online)
ISSN: 1573-398X (Print)

Volume 13, 4 Issues, 2017

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Current Respiratory Medicine Reviews

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Joseph Varon
The University of Texas Health Science Center
Houston, TX

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Resistin and Oxidative Stress as Markers of Atherosclerosis in Obstructive Sleep Apnea

Current Respiratory Medicine Reviews, 10(2): 131-137.

Author(s): Radostina Vlaeva Cherneva, Ognian Borisov Georgiev, Daniela Stoichkova Petrova, Dinko Georgiev Valev and Julia Ivanova Petrova.

Affiliation: Division of Pulmonary Medicine, Medical University, Sofia; Georgi Sofiiski 1str, Sofia, 1431, Pierce O'Macchoni 7str, ap.3. Bulgaria.


Introduction: Cardiovascular (CV) morbidity is increased in patients with obstructive sleep apnea (OSA). Oxidative stress and adipose tissue dysfunction are thought to be important factors for the accelerated atherosclerosis in OSA. The role of the various adipokines is however debated.

Aim: The aim of the study was to check whether resitin may be a link between oxidative stress, adiposity and atherosclerosis in OSA patients.

Methods: The common carotid artery (CCA) intima-media thickness (IMT), was measured by ultrasonography in 34 nondiabetic, non-hypertensive patients with untreated OSA. Oxidative stress (urinary 8-isoprostane levels) was measured by mass spectrometry (Cayman Chemical, USA). Insulin resistance was assessed by the homeostasis model assessment for insulin resistance (HOMA-IR). Resistin plasma levels were determined by an ELISA kit. Results: Urinary 8-isoprostanes, but not resistin were associated with the IMT after adjustment for CV risk factors, including HOMA-IR. Resistin levels increased with the degree of OSA severity, but did not correlate to markers of insulin resistance (HOMA-IR) or atherosclerosis. They were, however, associated with the time of sleep at SaO2<90% but not with the urinary 8-isoprostane levels.

Conclusion: In non-diabetic, non-hypertensive OSA patients, resistin plasma levels do not correlate to markers of adiposity, insulin resistance or oxidative stress. IMT was associated only with the levels of oxidative stress (8-urinary isoprostanes).


Atherosclerosis, insulin resistance, obstructive sleep apnea, oxidative stress, resistin.

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Article Details

Volume: 10
Issue Number: 2
First Page: 131
Last Page: 137
Page Count: 7
DOI: 10.2174/1573398X10666140723172355
Price: $58
13th Asthma & COPD

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