Rhinosinusitis in the Pediatric Patient with Cystic Fibrosis

ISSN: 1875-6336 (Online)
ISSN: 1573-3963 (Print)


Volume 10, 4 Issues, 2014


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Current Pediatric Reviews

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Editor-in-Chief:
Giuseppe Buonocore
Department of Molecular and Developmental Medicine
University of Siena
Siena
Italy


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Rhinosinusitis in the Pediatric Patient with Cystic Fibrosis

Author(s): Christopher Fundakowski, Rosemary Ojo and Ramzi Younis

Affiliation: 900 NW 17th St., Bascom Palmer Eye Institute, Suite 308, Department of Otolaryngology, University of Miami – Miller School of Medicine, Miami, FL 33136, USA.

Abstract

Cystic fibrosis (CF) is a common autosomal recessive genetic disorder where a deletion mutation and subsequent downstream alteration in transmembrane regulator proteins results in increased mucus viscosity. CF manifests clinically with chronic multisystem inflammation and recurrent infections. Nearly all children with CF have chronic sinusitis, and a large majority will have concurrent sinonasal polyposis. Chronic sinusitis and sinonasal polyposis in pediatric patients with CF can be managed conservatively initially, though most will fail medical management and require surgical intervention. Unfortunately, symptom resolution is marginal and polyp recurrence rates are high. Currently, no cure exists for CF and the mainstay of treatment is to provide symptomatic relief, and minimize disease morbidity.

Keywords: Pediatric, cystic fibrosis, rhinosinusitis, sinusitis.

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Article Details

Volume: 10
Issue Number: 3
First Page: 198
Last Page: 201
Page Count: 4
DOI: 10.2174/1573396309666131209205748
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