Allergic Aspergillosis and the Antigens of Aspergillus fumigatus

ISSN: 1875-5550 (Online)
ISSN: 1389-2037 (Print)

Volume 18, 12 Issues, 2017

Download PDF Flyer

Current Protein & Peptide Science

This journal supports open access

Aims & ScopeAbstracted/Indexed in

Submit Abstracts Online Submit Manuscripts Online

Ben M. Dunn
Department of Biochemistry and Molecular Biology University of Florida
College of Medicine, P.O. Box 100245, Gainesville
Florida, FL 32610-0245

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.441
5 - Year: 2.705

Allergic Aspergillosis and the Antigens of Aspergillus fumigatus

Current Protein & Peptide Science, 15(5): 403-423.

Author(s): Bharat Singh, Seema Singh, Abdul R. Asif, Michael Oellerich and Gainda L Sharma.

Affiliation: CSIR-Institute of Genomics and Integrative Biology, University Campus, Mall Road, Delhi-110007, India.


Incidence of fungal infections has increased alarmingly in past few decades. Of the fungal pathogens, the Aspergillus fumigatus has been a major cause of allergic bronchopulmonary aspergillosis (ABPA) which has five main stages - the acute, remission, exacerbation, glucocorticoid dependent and fibrotic stage. The diagnosis of ABPA remains difficult due to its overlapping clinical and radiological features with tuberculosis and cystic fibrosis. From past few decades, the crude fractions of A. fumigatus have been used for immunodiagnosis of ABPA. Most of the detection kits based on crude fractions of A. fumigatus are quite sensitive but have low specificity. Till date 21 known and 25 predicted allergens of A. fumigatus have been identified. Of these allergens, only five recombinants (rAsp f1-f4 and f6) are commercially used for diagnosis of allergic aspergillosis. Remaining allergens of A. fumigatus have been restricted for use in specific diagnosis of ABPA, due to sharing of common antigenic epitopes with other allergens. Complete sequencing of A. fumigatus genome identified 9926 genes and the reports on the proteome of A. fumigatus have shown the presence of large number of their corresponding proteins in the pathogen. The analysis of immunoproteomes developed from crude fractions of A. fumigatus by IgG/IgE reactivity with ABPA patients and animal sera have identified the panel of new antigens. A brief description on the current status of A. fumigatus antigens is provided in this review. The implementation of advance recombinant expression and peptidomic approaches on the A. fumigatus antigens may help in the selection of appropriate molecules for the development of tools for more specific early diagnosis of ABPA, and desensitization therapies for patients of allergic disorders.


Allergic aspergillosis, allergens, desensitization, diagnosis, recombinants.

Purchase Online Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 15
Issue Number: 5
First Page: 403
Last Page: 423
Page Count: 21
DOI: 10.2174/1389203715666140512120605
Price: $58
Global Biotechnology Congress 2017Drug Discovery and Therapy World Congress 2017

Related Journals

Related eBooks

Webmaster Contact: Copyright © 2017 Bentham Science