The Utility of Metformin Therapy in Reproductive-Aged Women with Polycystic Ovary Syndrome (PCOS)

ISSN: 1873-4316 (Online)
ISSN: 1389-2010 (Print)

Volume 16, 12 Issues, 2015

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Current Pharmaceutical Biotechnology

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Zeno Foldes-Papp
Visiting Professor of Medical Biochemistry
HELIOS Clinical Center of Emergency Medicine
Department for Internal Medicine
Alte-Koelner-Strasse 9
D-51688 Koeln-Wipperfuerth

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The Utility of Metformin Therapy in Reproductive-Aged Women with Polycystic Ovary Syndrome (PCOS)

Current Pharmaceutical Biotechnology, 15(1): 70-83.

Author(s): Nisha Nathan and Shannon D Sullivan.

Affiliation: Department of Endocrinology, Washington Hospital Center, 110 Irving Street, NW, Suite 2A-72, Washington, DC 20010, USA.


Metformin, an insulin-sensitizing drug commonly used to treat Type 2 Diabetes Mellitus (T2DM), has been increasingly used off-label for the treatment of polycystic ovary syndrome (PCOS), which affects at least 5-10% of reproductive- age women. With very little risk associated with its use, metformin provides many important benefits to women with PCOS, including regulating menstrual cycles, improving clinical signs of hyperandrogenism, ameliorating metabolic syndrome, inducing ovulation, improving pregnancy rates and pregnancy outcomes, preventing gestational diabetes, and preventing progression to T2DM. Here, we review the indications for metformin in women with PCOS, with a focus on the use of metformin during pre-conception and pregnancy.


Gestational diabetes mellitus, hirsutism, infertility, insulin resistance, metabolic syndrome, metformin, polycystic ovary syndrome, pregnancy.

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Article Details

Volume: 15
Issue Number: 1
First Page: 70
Last Page: 83
Page Count: 14
DOI: 10.2174/1389201015666140330195142

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