Progress in Development of Group A Streptococcus Vaccines

ISSN: 1873-4316 (Online)
ISSN: 1389-2010 (Print)

Volume 17, 15 Issues, 2016

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Current Pharmaceutical Biotechnology

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Zeno Foldes-Papp
Christian Clinical Center Siegen-Kreuztal

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Progress in Development of Group A Streptococcus Vaccines

Current Pharmaceutical Biotechnology, 14(11): 947-950.

Author(s): Yingli Song, Xiaolan Zhang, Chunmei Lu, Fengmin Zhang and Hui Zhu.

Affiliation: Department of Physiology, Harbin Medical University, Harbin 150081, China


Streptococcus pyogenes or Group A Streptococcus (GAS) is a major Gram-positive human pathogen that causes diverse human diseases with a high morbidity and mortality worldwide. The development of an effective GAS vaccine is hindered by the occurrence of many unique GAS serotypes, the complexity of the global epidemiology of GAS infections, and safety concerns over the cross-reactivity of some antigen-specific antibodies with human tissues and proteins. Although no licensed GAS vaccine is available, a number of candidate vaccines have been or are being evaluated in laboratory or in clinical trials. This minireview provides brief information on the progress and difficulty in the development of GAS vaccines.


Arginine deiminase, Group A Streptococcus, Group A carbohydrate, M protein, ScpA, Shr, SpyCEP, SsE, Streptococcal fibronectin-binding proteins, Streptococcal pyrogenic exotoxins, Trigger factor, Vaccine.

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Article Details

Volume: 14
Issue Number: 11
First Page: 947
Last Page: 950
Page Count: 4
DOI: 10.2174/1389201014666131226125540
Price: $58
Pharmaceutical Microbiology 2017

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