Simultaneous Determination of Antidiabetic Thiazolidinediones using Flow through Voltammetric Sensor
Lai-Hao Wang and Yan-Lin SongAffiliation:
Department of Medical Chemistry, Chia Nan University of Pharmacy and Science, 60 Erh-Jen Road, Section 1, Jen Te, Tainan 71743, Taiwan.
AbstractWe develop a method that uses flow through voltammetric sensor to quantitatively determine thiazolidine-2, 4-diones (TZDs) derivative which are pioglitazone, rosiglitazone and troglitazone. The method is using a gold electrode. The dynamic range for determining thiazolidine-2, 4-diones (TZDs) are extended by more than two orders of magnitude. The quantification limits are 0.10, 23, 15, 0.005 ng for thiazolidine-2, 4-dione, pioglitazone, rosiglitazone and troglitazone, respectively. The method can be applied to the quantitatively determining pioglitazone and rosiglitazone in antidiabetic drugs. Findings using high-performance liquid chromatography with a flow-through voltammetric detector and ultraviolet detector are comparable.
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