Synthesis, Characterisation of β-indolylketones and the Effect of Lipophilicity on the Antimicrobial Activity

ISSN: 1875-676X (Online)
ISSN: 1573-4129 (Print)


Volume 11, 4 Issues, 2015


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Current Pharmaceutical Analysis

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Laboratory of Analytical Chemistry
University of Athens
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Synthesis, Characterisation of β-indolylketones and the Effect of Lipophilicity on the Antimicrobial Activity



Current Pharmaceutical Analysis, 10(4): 284-292.

Author(s): Y.L.N. Murthy, Praveen Choppara, Y.V. Prasad and TJU Ranjan.

Affiliation: Department of Organic Chemistry, Foods, Drugs & Water, Andhra University, Visakhapatnam, 530 003, India.

Abstract

Herein, we report cellulose sulfuric acid (CSA) as a heterogeneous, eco-friendly, reusable catalyst for the synthesis of β -indolylketones via conjugate Micheal addition reactions of indoles, to chalcones in acetonitrile at 80 °C for 1.5–4 h. The structures of the synthesized compounds were evaluated by spectral data. All the synthesized compounds were screened for their antimicrobial activity against bacterial (S. aureus, K. pneumonia and S. marcescens) and fungal (C. albicans and A. niger) strains. The aim of this study was to determine the relationship between lipophilicity and antimicrobial activity of β-indolylketones.




Keywords:

β-indolylketones, cellulose sulfuric acid, chalcones, indoles, in vitro antimicrobial activity, lipophilicity, michael addition.



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Article Details

Volume: 10
Issue Number: 4
First Page: 284
Last Page: 292
Page Count: 9
DOI: 10.2174/1573412910666140630165745
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