Synthesis, Characterisation of β-Indolylketones and the Effect of Lipophilicity on the Antimicrobial Activity

ISSN: 1875-676X (Online)
ISSN: 1573-4129 (Print)


Volume 10, 4 Issues, 2014


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Synthesis, Characterisation of β-Indolylketones and the Effect of Lipophilicity on the Antimicrobial Activity

Author(s): Y. L.N. Murthy, Praveen Choppara, Y. V. Prasad and T. J.U. Ranjan

Affiliation: Department of Organic Chemistry, Foods, Drugs & Water, Andhra University, Visakhapatnam, 530 003, India.

Abstract

Here in, we report cellulose sulfuric acid (CSA) as a heterogeneous eco friendly, reusable, catalyst for the synthesis of β-indolylketones via conjugate Micheal addition reactions of indoles, to chalcones in acetonitrile at 80 oC for 1.5–4 h. The structures of the synthesised compounds were evaluated by spectral data. All the synthesized compounds were screened for their antimicrobial activity against bacterial (S. aureus, K. pneumonia and S. marcescens) and fungal (C. albicans and A. niger) strains. The aim of this study was to determine the relationship between lipophilicity and antimicrobial activity of β-indolylketones.

Keywords: β-indolylketones, cellulose sulfuric acid, chalcones, indoles, in vitro antimicrobial activity, lipophilicity, Michael addition

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Article Details

Volume: 10
First Page: 1
Last Page: 9
Page Count: 9
DOI: 10.2174/1573412910666140630165745
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