Determination of the New Antiplatelet Agent Ticagrelor in Tablets by Stability-Indicating HPLC Method

ISSN: 1875-676X (Online)
ISSN: 1573-4129 (Print)

Volume 13, 6 Issues, 2017

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Current Pharmaceutical Analysis

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Anastasios Economou
Department of Chemistry
Laboratory of Analytical Chemistry
University of Athens

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Determination of the New Antiplatelet Agent Ticagrelor in Tablets by Stability-Indicating HPLC Method

Current Pharmaceutical Analysis, 10(4): 279-283.

Author(s): Caren Gobetti, Rubia Lazzaretti Pereira, Andreas Sebastian Loureiro Mendez and Cássia Virginia Garcia.

Affiliation: Av. Ipiranga 2752, Sala 406. CEP 90610-000, Porto Alegre-RS, Brazil.


Ticagrelor is an orally active, reversibly bind of the P2Y12 receptor that can prevent ADP-mediated platelet activation and has a faster onset of action than clopidogrel. A stability-indicating HPLC method for the determination of ticagrelor in coated tablets was developed and validated. Chromatographic analysis was performed in a Shimadzu liquid chromatograph, equipped with Phemomenex® C18 column (250 x 4.6 mm, 5 μm), using a mobile phase composed of acetonitrile: water with 0.5% triethylamine (57:43 v/v) pH 7.0, at 0.7 ml/min flow rate and injection volume of 20 μl. Under the conditions established, the method demonstrated to be specific, without interference from formulation excipients, stability- indicating, linear (r = 0.9990) in the concentration range of 45.0 to 105.0 μg/ml, precise (RSD=0.71), accurate (99.61% of mean recovery) and robust. It can be successfully applied to ticagrelor tablets quality control, being adequate for routine analysis.


Antiplatelet, HPLC, quality control, stability-indicating assay, tablets, ticagrelor.

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Article Details

Volume: 10
Issue Number: 4
First Page: 279
Last Page: 283
Page Count: 5
DOI: 10.2174/1573412910666140610211656
Price: $58

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