Antitubercular Natural Terpenoids: Recent Developments and Syntheses

ISSN: 1875-6271 (Online)
ISSN: 1570-1794 (Print)


Volume 12, 6 Issues, 2015


Download PDF Flyer




Current Organic Synthesis

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 28th of 57 in Chemistry, Organic

Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Eduardo A. Castro
Universidad Nacional de La Plata
Buenos Aires
Argentina


View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.117
5 - Year: 2.425

Antitubercular Natural Terpenoids: Recent Developments and Syntheses



Current Organic Synthesis, 11(4): 545-591.

Author(s): Estibaliz Sansinenea and Aurelio Ortiz.

Affiliation: Facultad de Ciencias Quimicas de la Benemerita Universidad Autonoma de Puebla, Puebla Pue., 72570, Mexico.

Abstract

Tuberculosis (TB), mainly caused by Mycobacterium tuberculosis, is the leading killer among all infectious diseases worldwide and is responsible for more than two million deaths annually. The recent increase in the number of multi-drug resistant clinical isolates of M. tuberculosis has created an urgent need for the discovery and development of new antituberculosis leads. This review covers recent reports terpenoids that have demonstrated moderate to high activity in bioassays realized in vitro against M. tuberculosis; their organic synthesis is included in some cases. In this review, monoterpenoids, diterpenoids, sesquiterpenes, sesterterpenes and triterpenes, their structural analogs and semisynthetic derivatives will be discussed, with particular emphasis on the reported syntheses for each compound.




Keywords:

Antitubercular natural products, synthesis of natural terpenoids, terpenoids, tuberculosis.



Purchase Online Order Reprints Order Eprints Rights and Permissions




Article Details

Volume: 11
Issue Number: 4
First Page: 545
Last Page: 591
Page Count: 47
DOI: 10.2174/1570179411666140321180629
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2015 Bentham Science