Antitubercular Natural Terpenoids: Recent Developments and Syntheses

ISSN: 1875-6271 (Online)
ISSN: 1570-1794 (Print)

Volume 12, 6 Issues, 2015

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Eduardo A. Castro
Universidad Nacional de La Plata
Buenos Aires

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Antitubercular Natural Terpenoids: Recent Developments and Syntheses

Author(s): Estibaliz Sansinenea and Aurelio Ortiz

Affiliation: Facultad de Ciencias Quimicas de la Benemerita Universidad Autonoma de Puebla, Puebla Pue., 72570, Mexico.


Tuberculosis (TB), mainly caused by Mycobacterium tuberculosis, is the leading killer among all infectious diseases worldwide and is responsible for more than two million deaths annually. The recent increase in the number of multi-drug resistant clinical isolates of M. tuberculosis has created an urgent need for the discovery and development of new antituberculosis leads. This review covers recent reports terpenoids that have demonstrated moderate to high activity in bioassays realized in vitro against M. tuberculosis; their organic synthesis is included in some cases. In this review, monoterpenoids, diterpenoids, sesquiterpenes, sesterterpenes and triterpenes, their structural analogs and semisynthetic derivatives will be discussed, with particular emphasis on the reported syntheses for each compound.

Keywords: Antitubercular natural products, synthesis of natural terpenoids, terpenoids, tuberculosis.

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Article Details

Volume: 11
Issue Number: 4
First Page: 545
Last Page: 591
Page Count: 47
DOI: 10.2174/1570179411666140321180629

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