Approaches to the Total Synthesis of Natural Quinolizidine Alkaloid (+)-Epiquinamide and its Isomers: An Overview+

ISSN: 1875-6271 (Online)
ISSN: 1570-1794 (Print)


Volume 11, 6 Issues, 2014


Download PDF Flyer




Current Organic Synthesis

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 23rd of 58 in Chemistry, Organic

Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Prof. Eduardo A Castro
Universidad Nacional de La Plata
Buenos Aires
Argentina


View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.439
5 - Year: 2.778

Approaches to the Total Synthesis of Natural Quinolizidine Alkaloid (+)-Epiquinamide and its Isomers: An Overview+

Author(s): U. Chinna Rajesh, Archana Gupta and Diwan S. Rawat

Affiliation: Department of Chemistry, University of Delhi, Delhi-110007, India.

Abstract

Alkaloids isolated from the amphibian skin have shown interesting biological profiles especially relevant to neurology. The skin of the Ecuadorian frog tricolor has provided novel quinolizidine alkaloid epiquinamide, albeit in the minute quantities (240 µg from 183 frogs) representing a new class of nicotinic agonists in CNS disorders. Significant efforts have been devoted to the stereoselective synthesis of epiquinamide and its isomers with different strategies since 2005. Till date, about sixteen total syntheses of natural epiquinamide and its isomers have been published. This review aims to analyze the advances in the developed strategies and methodologies for stereoselective total syntheses of target molecule epiquinamide.

Keywords: Curtius rearrangement, epiquinamide, Grignard reaction, 1-hydroxyquinolizidinone, quinolizidine alkaloid, radical cyclization, ring closing metathesis, sharpless asymmetric dihydroxylation

Purchase Online Rights and Permissions

  
  



Article Details

Volume: 11
First Page: 1
Last Page: 20
Page Count: 20
DOI: 10.2174/1570179411666140321180414
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science