Syntheses and Functionalizations of Porphyrin Macrocycles

ISSN: 1875-6271 (Online)
ISSN: 1570-1794 (Print)


Volume 11, 6 Issues, 2014


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Prof. Eduardo A Castro
Universidad Nacional de La Plata
Buenos Aires
Argentina


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Syntheses and Functionalizations of Porphyrin Macrocycles

Author(s): Maria da G.H. Vicente and Kevin M. Smith

Affiliation: Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana 70803, USA.

Abstract

Porphyrin macrocycles have been the subject of intense study in the last century because they are widely distributed in nature, usually as metal complexes of either iron or magnesium. As such, they serve as the prosthetic groups in a wide variety of primary metabolites, such as hemoglobins, myoglobins, cytochromes, catalases, peroxidases, chlorophylls, and bacteriochlorophylls; these compounds have multiple applications in materials science, biology and medicine. This article describes current methodology for preparation of simple, symmetrical model porphyrins, as well as more complex protocols for preparation of unsymmetrically substituted porphyrin macrocycles similar to those found in nature. The basic chemical reactivity of porphyrins and metalloporphyrin is also described, including electrophilic and nucleophilic reactions, oxidations, reductions, and metal-mediated cross-coupling reactions. Using the synthetic approaches and reactivity profiles presented, eventually almost any substituted porphyrin system can be prepared for applications in a variety of areas, including in catalysis, electron transport, model biological systems and therapeutics.

Keywords: Aromaticity, porphyrin, pyrrole, reactivity, substitutions, synthesis.

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Article Details

Volume: 11
Issue Number: 1
First Page: 3
Last Page: 28
Page Count: 26
DOI: 10.2174/15701794113106660083
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