Synthesis of Iminosugars from Tetroses

ISSN: 1875-6271 (Online)
ISSN: 1570-1794 (Print)


Volume 11, 6 Issues, 2014


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Editor-in-Chief:
Prof. Eduardo A Castro
Universidad Nacional de La Plata
Buenos Aires
Argentina


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Synthesis of Iminosugars from Tetroses

Author(s): Cristina E. Sousa, Raquel R. Mendes, Flora T. Costa, Vera C.M. Duarte, António G. Fortes and Maria J. Alves

Affiliation: Departamento de Química, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal.

Abstract

Iminosugars continue receiving a great deal of attention from chemists and biochemists for their potential as pharmaceutics. This is a comprehensive review of the methods found in the literature for the synthesis of piperidine, pyrrolidine, indolizidine, and pirrolizidine iminosugars, starting from D/L-erythrose and D/L-threose carbon chains (tetroses). This review shows the crescent popularity of small molecules to build up iminosugar molecules. Methodologies described herein utilize inexpensive commercial materials. The synthesis of the four tetroses is included referring old and modern methodologies.




Keywords: Erythose, indolizidines, piperidines, pyrrolidines, pyrrolizidines, threose.

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Article Details

Volume: 11
Issue Number: 2
First Page: 182
Last Page: 203
Page Count: 22
DOI: 10.2174/15701794113106660074
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