Organocatalysed Cyanations of Carbonyl Compounds
Dina Murtinho and M. Elisa Silva SerraAffiliation:
Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade de Coimbra 3004-535 Coimbra, Portugal.
AbstractOne of the most important carbon−carbon bond forming reactions in organic synthesis is the cyanation of carbonyl compounds. The resulting cyanohydrins are keybuilding blocks for many other important compounds, namely, α-hydroxy acids, α-hydroxy ketones, primary and secondary β-hydroxy amines, α-hydroxy esters and α-amino acids, which are essential in areas such as fine chemistry, agrochemicals and pharmaceuticals. Cyanohydrin synthesis can be catalyzed by enzymes, metal complexes, inorganic and organic compounds. The initial synthetic methods have been extensively explored however the organocatalyzed reaction has been referred to in more limited extent. In this paper we will review the cyanation of aldehydes and ketones in the presence of organocatalysts, addressing both the formation of racemic and non-racemic cyanohydrins.
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