L-Proline Catalyzed Synthesis of Structurally Diverse 1,4- dihydropyridines Fused with Medicinally Privileged Heterocyclic Systems
Sarita Khandelwal, Anshu Rajawat and Mahendra KumarAffiliation:
Department of Chemistry, University of Rajasthan, Jaipur, 302004, India.
AbstractStructurally diverse unsymmetrically annulated 1,4-dihydropyridines have been synthesized by L-proline catalyzed four-component domino protocol involving the reaction of 2-aminobenzothiazole, thiophene-2-carbaldehyde and carbonyl compounds in ethanol. The utilization of L-proline in the multicomponent reaction will make the present protocol attractive for synthesis of 1,4-dihydropyridines in terms of reaction efficiency, atom-economy and environmental safety.
2-aminobenzothiazole, 1, 4-dihydropyridines, chromenoindenopyridines, chromenoquinolines, indenoquinolines, Knoevenagel condensation, medicinally privileged heterocycles, Michael addition, multicomponent reaction, organocatalysis, L-proline, pyranoquinolines.
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