L-Proline Catalyzed Synthesis of Structurally Diverse 1,4- dihydropyridines Fused with Medicinally Privileged Heterocyclic Systems

ISSN: 2213-3380 (Online)
ISSN: 2213-3372 (Print)


Volume 1, 2 Issues, 2014






Current Organocatalysis

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Editor-in-Chief:
Bimal K. Banik
Vice President of Research & Education Development
Community Health Systems of South Texas (CHSST)
Edinburg, Texas
USA


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L-Proline Catalyzed Synthesis of Structurally Diverse 1,4- dihydropyridines Fused with Medicinally Privileged Heterocyclic Systems

Author(s): Sarita Khandelwal, Anshu Rajawat and Mahendra Kumar

Affiliation: Department of Chemistry, University of Rajasthan, Jaipur, 302004, India.

Abstract

Structurally diverse unsymmetrically annulated 1,4-dihydropyridines have been synthesized by L-proline catalyzed four-component domino protocol involving the reaction of 2-aminobenzothiazole, thiophene-2-carbaldehyde and carbonyl compounds in ethanol. The utilization of L-proline in the multicomponent reaction will make the present protocol attractive for synthesis of 1,4-dihydropyridines in terms of reaction efficiency, atom-economy and environmental safety.




Keywords: 2-aminobenzothiazole, 1, 4-dihydropyridines, chromenoindenopyridines, chromenoquinolines, indenoquinolines, Knoevenagel condensation, medicinally privileged heterocycles, Michael addition, multicomponent reaction, organocatalysis, L-proline, pyranoquinolines.

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Article Details

Volume: 1
Issue Number: 1
First Page: 51
Last Page: 58
Page Count: 8
DOI: 10.2174/22133372114016660004
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