Marine Toxin Structure Elucidation by Mass Spectrometry

ISSN: 1875-5348 (Online)
ISSN: 1385-2728 (Print)

Volume 19, 24 Issues, 2015

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Atta-ur-Rahman, FRS
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Kings College
University of Cambridge

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Marine Toxin Structure Elucidation by Mass Spectrometry

Author(s): Pengyuan Liu

Affiliation: Center for Intelligent Chemical Instrumentation, Department of Chemistry and Biochemistry, Clippinger Laboratories, Ohio University, Athens, Ohio 45701, United States.


Mass spectrometry (MS) analysis plays an important role in the structural elucidation of natural marine toxins. In MS analysis, the chemical structural elucidation is mainly achieved by tandem MS (MS/MS) and multiple stage MS (MSn) techniques, in which fragmented product ions are used to interpret precursor ion structures. Herein we discuss the MS/MS and MSn behaviors of major marine toxins, such as domoic acid, anatoxins, saxitoxins, tetrodotoxins, okadaic acid, dinophysistoxins, azaspiracids, gymnodimines, spirolides, pinnatoxins, brevetoxins, ciguatoxins, yessotoxins, brevisulcenal-F, palytoxins, and protein/peptide toxins like conotoxins. In this review, our primal focus is on organization of literature data after 2000.

Keywords: Fragmentation pathway, marine toxin, mass spectrometry, multiple stages mass spectrometry, structural elucidation, tandem mass spectrometry.

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Article Details

Volume: 18
Issue Number: 7
First Page: 812
Last Page: 822
Page Count: 11
DOI: 10.2174/138527281807140515145401

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