Macrolactins: Antitumor Antibiotics as Marine Drug Lead

ISSN: 1875-5348 (Online)
ISSN: 1385-2728 (Print)

Volume 19, 24 Issues, 2015

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Current Organic Chemistry

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Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge

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Macrolactins: Antitumor Antibiotics as Marine Drug Lead

Current Organic Chemistry, 18(7): 804-811.

Author(s): Tingting Wang, Shan He, Xiaojun Yan and Peng Zhu.

Affiliation: Key Laboratory of Applied Marine Biotechnology of Ministry of Education, Ningbo University, Ningbo 315211, China.


Macrolactins are secondary metabolites mainly from marine microorganisms bearing a unique 24-membered lactone core structure. Since their first occurrence in 1989, they have attracted considerable attention from natural product chemists, organic chemists, and pharmacologists due to their chemical complexity, potent antimicrobial and antitumor activities. Some of them are serving as lead compounds for drug discovery. Although a number of synthetic approaches have been developed, sample supply remains a big issue which precludes further investigation of pharmacological application and mechanisms of action. This review summarizes current knowledge about macrolactins including their chemical diversity, biological activities, synthetic studies, and efficient preparation.


Antibiotic, antitumor, chemical diversity, efficient preparation, macrolactins, synthesis.

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Article Details

Volume: 18
Issue Number: 7
First Page: 804
Last Page: 811
Page Count: 8
DOI: 10.2174/138527281807140515144549

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